The Islamic State of Iraq and Syria (ISIS) conducted two attacks in late May 2025 targeting transitional government forces in eastern Suwayda Province, demonstrating that ISIS retains a presence along ground lines of communication (GLOC) between the central Syrian desert and southern Syria. ISIS fighters detonated improvised explosive devices (IEDs) targeting Syrian Ministry of Defense (MoD) vehicles in separate attacks in Tulul al Safa on May 22 and 28. These IED attacks are the first attacks that ISIS has claimed in southern Syria since 2023 and the first attacks that ISIS has claimed against the Syrian transitional government. The attacks targeted vehicles from the Free Syrian Army and the 70th Division, which are Syrian opposition units that are supported by the United States in the al Tanf Deconfliction Zone. ISIS has probably maintained attack cells in southern Syria and along the GLOCs leading to central Syria since 2023 despite the lack of attacks. ISIS claimed a large number of attacks in Daraa Province in 2023 that it had conducted months prior.
These attacks demonstrate that ISIS maintains cells between the central Syrian desert and southern Syria, where the group has historically sheltered some senior leadership in recent years. ISIS fighters could use the GLOCs between southern and central Syria to retreat from southern Syria into central Syria or vice versa when under pressure. ISIS uses central Syria’s sparsely populated desert as a sanctuary where it can rest, refit, and train new fighters. ISIS maintained likely support zones in eastern Suwayda Province in 2022, and the Assad regime ambushed ISIS “supply” vehicles in Tulul al Safa in June 2022, demonstrating that ISIS previously operated in this rural area and used it to resupply fighters. ISIS announced in mid-May 2025 that it has a growing presence in the “countryside and [city] outskirts” in Syria, but historic ISIS activity in eastern Suwayda suggests that these attacks are not part of the group’s alleged expansion.
These IED attacks are part of a trend of increased activity by Salafi-jihadi groups in Syria in May 2025, however. Syrian Interior Ministry Spokesperson Noureddine al Baba said that ISIS activity has spiked in the period since the fall of the Assad regime due to ISIS cells’ seizure of former Assad regime weapons. The transitional government has conducted three large-scale raids targeting ISIS cells in Aleppo, Rif Dimashq, and Deir ez Zor provinces since May 17, compared to three counter-ISIS raids between December 2024 and early May.[
Key Takeaways:
- ISIS Activity in Syria: The Islamic State of Iraq and Syria (ISIS) conducted two attacks in late May 2025 targeting transitional government forces in eastern Suwayda Province, demonstrating that ISIS retains a presence along ground lines of communication (GLOC) between the central Syrian desert and southern Syria. ISIS fighters detonated improvised explosive devices (IEDs) targeting Syrian Ministry of Defense (MoD) vehicles in separate attacks in Tulul al Safa on May 22 and 28. These IED attacks are the first attacks that ISIS has claimed in southern Syria since 2023 and the first attacks that ISIS has claimed against the Syrian transitional government. ISIS has probably maintained attack cells in southern Syria and along the GLOCs leading to central Syria since 2023 despite the lack of attacks.
- Cooperation Between Iran, Russia, and China: Iran continues to coordinate with China and Russia on nuclear and economic issues, which illustrates cooperation between major US adversaries. Russia has opposed stated US objectives in the nuclear negotiations by supporting Iran’s “right” to enrich uranium. Russian Permanent Representative to the UN in Vienna, Mikhail Ulyanov, stated on May 30 that the US-Iran nuclear negotiations may "require" another round of trilateral deputy-level consultations between Iran, China, and Russia. The Iranian, Chinese, and Russian permanent representatives to the UN reportedly met on May 29 to coordinate positions on the US-Iran nuclear negotiations.
- Gulf Countries' Concerns about Regional Escalation: Gulf leaders are reportedly urging Iran and the United States to conclude a nuclear deal. Gulf countries likely support a US-Iran nuclear agreement because they are concerned that the collapse of the US-Iran nuclear negotiations could trigger a potential US or Israeli strike on Iran, which could in turn prompt an Iranian retaliation against Gulf states or oil trade routes. Saudi, Emirati, and Qatari leaders reportedly urged US President Donald Trump to prioritize a nuclear agreement with Iran and prevent military escalation during Trump’s recent Gulf visit in mid-May, according to three sources speaking to Axios on May 29. Unspecified sources similarly told Reuters on May 30 that Saudi Defense Minister Khalid bin Salman told Iranian leaders in April 2025 to “seriously” consider Trump’s proposal for a nuclear deal. Gulf countries may be concerned that Iran would attack US bases or energy infrastructure in the Gulf or close the Strait of Hormuz in retaliation for a US or Israeli strike on Iran.
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